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KMID : 0368819920310050837
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Journal of the Korean Neuropsychiatr Association
1992 Volume.31 No. 5 p.837 ~ p.845
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Effects of Psychotropic Drugs on Phsopholipase C and Protein Kinase C in Vitro
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Abstract
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The effects of various psychotropic drugs on phospholipase C(PLC) and protein kinase C(PKC) were studied in vitro. Trifluoperazine(TFP) and chlorpromazine(CPZ) strongly inhibited activities of both PLC and PKC, Fifty percent inhibition
concentration(I50) of TFP was 180μM for PLC and 270μM for PKC. I50s of CPZ for PLC and PKC were 270μM and 150μM. respectively. Haloperidol inhibited PLC (I50, 490μM), but did not inhibit PKC's. Diazepam inhibit PKC weakly(I50-2mM), but not
PLC
Sulpiride did not have any effects on both PLC and PKC. TFP inhibited PLC by competitive manner with phosphatidylinositol (Ki, 20μM). The inhibition of PKC by TFP was of noncompetitive type to calcium(Ki, 45μM).
These results suggest that the antipsychotic drugs could be classified by their effects on PLC and PKC.
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